Before antibiotics, syphilis was an incurable disease. Syphilitic patients were treated with mercury (calomel or mercury chloride), which conveyed toxic side effects.
The imposing threat of infection created a population of hypochondriacs called ‘syphilophobes’. A 1938 paper in the Canadian Medical Association Journal, featured seven case studies of syphilophobia which prompted Dr Frank Cormia to comment:
“A morbid fear of syphilis has been present in the human race ever since the great plague of the early sixteenth century.”
Adolf Hitler also succumbed to this particular neuroticism. In Hitler’s book “Mein Kampf”, he devoted several pages to syphilis which he called “the Jewish disease.” Several historians have tried to analyse Hitler’s syphilophobia*, and have come up with various explanations.
One controversial theory posits that the Führer may have contracted syphilis from a Jewish prostitute. Another theory suggests he thought that he inherited the disease or acquired it congenitally (Hitler believed that his father was half-Jewish and died of syphilis).
Hitler aside, syphilis was a condition that evoked extreme xenophobia. In Italy, it was called “the French disease”; In France, it was “the Italian disease”. The Dutch called it the “Spanish disease”; the Russians called it “the Polish disease”, and the Turks called it “the Frank disease.”
Given the toxicity of mercury treatment, the medical world needed a magic bullet: A discriminatory drug that would destroy bacterial cells but spare human ones. After testing 606 chemicals, Nobel prize-winning physician, Paul Ehrlich, discovered Salvarsan, a synthetic drug that effectively treated syphilis and sleeping sickness. Salvarsan, or compound 606, was the first magic bullet, the first chemotherapeutic agent!
Salvarsan would eventually be replaced by the modern cure, and preferred magic bullet, for syphilis: penicillin. The serendipitous discoverer of penicillin, Alexander Fleming, built a lucrative practice focused on treating wealthy patients suffering from syphilis. Here’s the kicker: Fleming treated his patients with Salvarsan. The sweet irony is that Fleming, who discovered penicillin, investigated penicillin’s effect on many microbes, but did not think of testing it as a treatment for syphilis!
*More generally, ‘cypridophobia’ is the intense fear of contracting a sexually-transmitted-disease. It is named after the Greek island, Cyprus, which was famous in ancient times as the birthplace of Aphrodite (the Greek equivalent of Venus) and for erotic worship rituals. Cyprian also means lewd woman or prostitute.