Whenever a patient consults me for warts, my internal monologue screams: “Let’s turn on the juice and see what shakes loose.”
This snippy Betelgeuse quote has a layered meaning because the treatment I use is, well, beetle juice; and it works by loosening cellular connections (acantholysis), thereby forming a skin blister which heals without scarring.
The defensive poison, called cantharidin, is harvested from blister beetles. It is a toxic chemical that blisters human skin on contact and protects beetles from predators.
Only male blister beetles produce cantharidin, which acts as a currency in reproductive transactions. Males secrete cantharidin from their joints and transfer it to females during mating (a nuptial gift). Females prefer males that are well-endowed with cantharidin because higher concentrations of the chemical provide a stronger protective coating for unhatched eggs. Prior to mating, female beetles sample the male’s secretions. If she is unimpressed with his cantharidin offering, she will reject his advances.
Not only humans find cantharidin useful. Nuthatch songbirds use blister beetles as a squirrel repellent. They grab the beetles in their beaks and rub the unfortunate insects against tree cavities which form the entrance to their nests.
You may have heard of cantharidin being referred to as “Spanish fly”–a folk medicine prepared from crushed beetles. Spanish fly has been used for various ailments but, most famously, established its popular reputation as an aphrodisiac. It is rumoured that the Roman empress Livia (58 BC – 29 AD) would put Spanish fly into the royal family’s food to grow their sexual appetites in the hope of catching them in disgrace and using the scandal to blackmail them. In reality, cantharidin is highly toxic to humans. The aphrodisiac myth probably started because ingestion of toxic doses irritates the genitourinary tract and can lead to priapism (persistent and painful erection) in males.
When 19th century French Legionnaires in North Africa were hospitalized for priapism, French Foreign Legion physicians discovered that the soldiers all ate frog-legs from local amphibians that had eaten blister beetles. [We don’t know if the frogs ate the blister beetles to protect themselves from the French.] A century before that, cantharidin was already in use among French aristocrats as an aphrodisiac. The Marquis de Sade famously laced sweets with Spanish fly. When it led to the poisoning of two prostitutes, he was sentenced to death. Almost 200 years later, in 1954, history repeated itself when Arthur Kendrick Ford was convicted for the deaths of two women when he secretly laced their candies with cantharidin in the hopes of firing up their libidos.
The French chemist, Pierre Robiquet, was the first person to isolate cantharidin. I don’t know whether he ate frog legs or not but Robiquet is best known for discovering codeine.